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KMID : 0376219930300010093
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Chonnam Medical Journal
1993 Volume.30 No. 1 p.93 ~ p.99
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A study on T and B lymphocyte fractions in peripheral blood of HBeAg positive chronic active hepatitis
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Abstract
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The pathogenesis of HBeAg positive chronic active hepatitis is suggested to be caused by the complex of defective immune regulation due to defective suppressor T lymphocyte and helper T lymphocyte, by the direct viral cytopathic effect due to persistent viral replication, and by the immune complex effects with hepatitis B vi￢rus. Although it is still controversial, most of the reports support the major role of cell-mediated immunity in the pathogenesis.
In order to seek the role of cell mediated immunity in the pathogenesis of CAH, we measured the serum concentration of aspartate aminotransferase(AST), alanine aminotransferase(ALT), alkaline phosphatase(ALP), T cell subsets and B cell with NK cell in control(8 cases) and 47 histologically proven HBeAg positive chronic ac￢tive hepatitis group.
The results were as follows.
1. The serum levels of AST, ALT of CAH were higher than those of controls (p<0.01), but the levels of ALP of CAH and control were in the normal ranges.
2. The serum levels of AST, ALT, ALP between mild, moderate, severe CAH by histological degree showed no statistically significant difference.
3. The populations of total T lymphocyte, T4 and T8 lymphocyte, B cell, NK cell and T4 /T8 ratio between control and CAH group were not significantly different.
4. The populations of total T lymphocyte, T4and T8 lymphocyte, B cell, NK cell, T4 /T8 ratio between subgroups of CAH were not significantly different.
In conclusion, liver cell damages in HBeAg positive chronic active hepatitis is considered not due to the changes of lymphocyte or it´s subsets.
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KEYWORD
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